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systemically examined the expression of GPxs in breast cancer cell lines and found that GPx5 and GPx7 were down-regulated in the human breast cancer MCF-7 and MDA-MB-231 cell lines and GPx6 was also down-regulated in MDA-MB-231cells compared with healthy breast MCF-10A cells [19]

doi: 10.1016/j.freeradbiomed.2018.07.018 76 BckerVCheungFYSivekeJTFandreyJWinningS

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However, extreme oxidation breaks the balance between the oxidative and antioxidant systems, resulting in oxidative stress and an excessive accumulation of ROS