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They are most effective when paired with balanced nutrition and exercise

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Given the significant unmet need for novel therapeutic interventions in AS, particularly as many patients still progress to KF despite current treatments like RASi, GLP-1 RAs may offer an innovative strategy to delay KF in AS, potentially addressing both metabolic and inflammatory pathways involved in CKD progression [40, 42, 56]

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Subsequently, it was further confirmed that UA alleviated Ti nanoparticle-induced osteoblastic ferroptosis and promoted osteoblast differentiation, but this effect was inhibited by silencing GPX4