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Preliminary data of a human study performed by a governmental research group at the RIVM (van Amsterdam et al., submitted for publication), comparing two commercial brands (one with low and one with high ammonia content) with respect to nicotine absorption, showed no difference in venous blood nicotine levels (no difference in total absorption and peak plasma of nicotine) when smoking the two brands

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Mice were treated with FLI-06 (1 mg/kg body weight), a specific Notch pathway inhibitor