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2019;13(SEP)

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It suppresses the IL-6/STAT3 pathway, thereby preventing the HCC cells from inhibiting the cytotoxic effect mediated by natural killer cells (NKs) ( + T cells and induce immunity to tumor rechallenge in Hepa16 allograft mice ( pos CD3 + T cells treated with exendin-4 secreted less IFN-, exhibited weaker migration ability, and upregulated genes related to apoptosis, immunoregulation, and immune deficiency, such as CASP3 and CASP7

The chemistry depends on copper coordination and may be influenced by pH, counterions, oxidation and competing chelators

36,37 Thus, the systemic equilibrium among glycolytic flux, TCA cycle activity, and gluconeogenic capacity constitutes a critical determinant of lactate homeostasis