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Caspase-8, for instance, is able to directly cleave pro-IL-1, thus activating (and not inhibiting), through signal transduction, the necroptotic pathway, which is known to culminate in cell lysis accompanied with inflammation [128]

However, their mechanisms of action are not fully understood and multiple signal pathways could be involved

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[DOI] [PubMed] [Google Scholar] Ebert R, Creutzfeldt W, Brown JC, Frerichs H, Arnold R

After trying both acetonitrile and methanol, acetonitrile was the optimal organic eluent, displaying distinctive LC signal in appropriate retention time for both SEMG and its internal standard