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For example, a patient with a history consistent with IgE-mediated reaction to the antimicrobial sulfonamide trimethoprim-sulfamethoxazole can receive celecoxib, chlorthiazide, furosemide or other nonantimicrobial sulfonamides, as indicated

Simultaneously, the elevated synovial fluid LPA levels enhanced FLS migration via the GPCR-PI3K/Akt axis, while the LPA antagonist Ki16425 inhibited synovial proliferation in an animal model (44)

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The role of glutathione in the transport and catabolism of nitric oxide