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Serious vaping side effects may include: Cryptogenic organizing pneumonia (COP), formerly known as idiopathic bronchiolitis obliterans with organizing pneumonia (BOOP) E-cigarette or vaping product use-associated lung injury (EVALI) Heart attacks Nicotine addiction Popcorn lung Seizures Severe lung injury Strokes According to a 2020 review published in The Journal of Physiology, e-cigarette exposure can reduce lung function, increase airway inflammation and weaken the immune system, increasing the risk of respiratory infections