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Nicotine, while addictive, not risk-free, and an important factor of why people smoke, is not the primary cause of diseases [2]

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Sustained NRF2 activation probably contributes to persistent antioxidant defense and cellular resilience during long-term oxidative challenge, consistent with observations that NRF2 signaling remains constitutively active in smoking-associated squamous carcinomas 29,30

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"Cigarette smoking, even experimentally, among children of any age should be strongly discouraged." The research, published Wednesday in the Journal of the American Heart Association, uses information from children and adolescents who were ages 6 to 19 in the 1970s to 1980s, with follow-up information from many of them as recently as 2018