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note in Nature Medicine , NNMT inhibition has been shown to enhance energy expenditure and promote fat loss, even without dietary modification (Kraus et al., Nature Medicine )

Strict Vegetarian or Vegan Diets: Since the primary sources of vitamin B12 are animal-derived, individuals following a strict vegetarian or vegan diet may find it challenging to intake adequate amounts of the vitamin

Patients should avoid online vendors selling them as research chemicals those products are not tested for human use and have been found in independent testing to vary dramatically in purity and concentration

Diabetes, Obesity & Metabolism