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In addition, better powered studies would probably have detected a much broader range of adverse biological effects associated with the additives than identified to those identified in PM's published papers suggesting that the published papers substantially underestimate the toxic potential combination of cigarette smoke and additives

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Over time, this significantly increases the likelihood of heart attacks, stroke, and peripheral artery disease (PAD)

Despite the traditional vape segment remaining niche, Japan is emerging as a major consumer of heated tobacco alternatives, reflecting strong consumer interest in reduced-risk smoking alternatives within legal constraints

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