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High concentrations of nicotine can kill

In January 2025, ONS signed onto a letter asking Congress to support 2025 appropriations bills that would allow the FDA to retain its authority to issue such rules as well as protect funding for the Centers for Disease Control and Preventions Office on Smoking and Health

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The results are expressed as adjusted geometric means (GMs) and ratio of GMs (RGMs) between smokers of menthol and non-menthol cigarette, by race/ethnicity

However, the amount of these substances is 9-450 times less in vapour compared to cigarette smoke