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Induction of GI Arrest and Apoptosis in a Conditional Expression Model of AML1/ETO: p53-Independent Upregulation of p21/WAF/CIPI1

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This direct exposure damages cells and increases the likelihood of mutations that can lead to cancer.The Nature Communications study highlighted that even moderate use of chewing tobacco over time can result in precancerous lesions and a faster progression to malignant tumors compared to cigarette smoking

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