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MI and its consequent tissue damage leading to heart failure are mainly responsible for the fatality in patients with T2DM

Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents

References Khavinson VKh

This can compromise mitochondrial membrane integrity and DNA, affecting normal ocular tissue function in TAO ( Inflammatory response: Oxidative stress promotes persistent inflammatory reactions that contribute to ocular tissue damage in TAO ( Mitochondrial oxidative stress likely plays a significant role in TAO pathogenesis by influencing thyroid function, damaging ocular tissues, and perpetuating inflammation

However, with significant weight loss comes an increased need for nutritional guidance to help patients maintain quality of life and avoid nutritional deficiencies commonly observed during caloric restriction