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Furthermore, a recent paper showed the existence of PINK1-mediated PARK2-independent mitophagy via recruitment of autophagy receptors, Optineurin, including calcium binding and coiled-coil domain 2 (CALCOCO2/NDP52) and Optineurin (OPTN) [48,49,50,51]

When exposed to nicotine, these cells release exosomestiny particles that transport cellular products and wastethat disrupt the iron balance in neurons, triggering symptoms often found in dementia patients

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Masadeh MM, Hussein EI, Alzoubi KH, Khabour O, Shakhatreh MA, Gharaibeh M