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E-cigarettes are also known to induce sleeping disorders as they engage different pathways in the brain responsible for addictive behavior, which is easily adopted during sleep deprivation

The study did not find neotame in the four e-cigarettes it tested that are authorized for sale by the Food and Drug Administration, nor in Juul, which has an application pending with the FDA

Furthermore, research from the National Institute on Drug Abuse (NIDA) indicates that polysubstance abuse can lead to more severe addiction and withdrawal symptoms

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