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Kathryn Wellen (University of Pennsylvania) for critical reading of our manuscript, Fran Vasquez for help with the CRISPR schematic, Uma Chandran and Jiefei Wang (UPMC Hillman Cancer Center Bioinformatics Core) for help with bioinformatic analysis of the CRISPR screen, and Maureen Lyons (UPMC Hillman Cancer Center Cancer Genomics Core) for help with sequencing of the CRISPR library