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Due to the promotive effect of GLP-1R agonism on -cells proliferation and survival, concerns of tumorigenesis, especially pancreatic cancers, have been raised about incretin-based therapies ( 4.5 Asthma Asthma is a very common chronic lung disease characterized by chronic persistent airway inflammation and airway remodeling, resulting in incompletely reversible airway obstruction, especially in advanced stages ( 5 Discussion The safety and efficacy of GLP-1RAs in the treatment of type 2 diabetes have been well demonstrated

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Randomized controlled trials The double-blind, placebo-controlled Nutritional Prevention of Cancer (NPC) study in 1,312 older adults with a history of nonmelanoma skin cancer found that supplementation with 200 g/day of selenium-enriched yeast (selenized yeast) for an average of 7.4 years resulted in a 52% decrease in prostate cancer incidence in men (81)