The most common reasons: using a standard (non-effervescent, non-liposomal) capsule with poor gut absorption, inconsistent daily use, expecting visible results before the typical 8-12 week window, unrealistic expectations set by marketing claims, low supporting nutrients like Vitamin C, or continued sun exposure without adequate sunscreen, which counteracts skin brightening effects
M1-dominant macrophages overproduce TNF- and IL-6, directly blocking insulin receptor signalling in metabolically active tissues [4]
It's also crucial to remember that maintaining the results requires continued use, along with a comprehensive skincare routine that includes sun protection, hydration, and a balanced diet
Many patients choose to use Sermorelin long-term for sustained benefits, while others use it cyclically or for specific periods of optimization
The choice depends on the research objective: pure regeneration (Glow) or regeneration + inflammatory control (Klow)