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Together, the presence of these signatures in nonmalignant, chronically exposed cells supports the idea that long-term cigarette exposure acts both as a genotoxic insult and as a selective pressure favoring cells capable of enduring genomic stress 20,26,27

10.1016/j.mce.2019.110507 133 LiguoriI.RussoG.CurcioF.BulliG.AranL.Della-MorteD.et al (2018)

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