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Whether the current rate appropriately balances the tradeoffs discussed above is unclear

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Systemic adeno-associated virus serotype (AAV) 9-mediated delivery of the circular RNA circAASS restored mitophagy and mitochondrial biogenesis in AKI models by both enhancing PINK1 expression and stabilizing PGC-1, resulting in reduced tubular injury and long-term fibrosis (Ma et al., 2025)