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Statements Author contributions JE-D and TF conceived and planned the work

Quitting smoking could be the key to improving not only your physical health, but your mental health too. If you want to stop smoking, talk to your pharmacy, ask at your GP surgery, or call your local Stop Smoking Service: Gateshead 0800 531 6317 South Tyneside 0191 424 7300 Sunderland Freephone 0800 531 6317 Northumberland NHS Stop Smoking Service 01670 813 135 North Tyneside NHS Stop Smoking Service 0345 2000 101 Newcastle NHS Stop Smoking Service 0191 269 1103 County Durham NHS Stop Smoking Service 0800 011 3405 Tees NHS Stop Smoking Service (Middlesbrough , Redcar and Cleveland , Stockton and Hartlepool) 01642 383 819 Darlington 0300 123 1044 (national quitline only)

Cells stimulated with CSE in the presence of GSK343 inhibitor significantly increased DAB2IP mRNA in comparison to the cells treated with CSE 20% alone

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At the time, filtered cigarettes were thought to be safer than unfiltered ones, so tobacco companies began marketing filtered cigarettes to men for the first time