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Are more oral GLP-1 medications being developed

Across n=95 trial participants, the authors reported over 20 weeks a weight reduction of -15.7 percent (cagrilintide 1.2 mg) and -17.1 percent (cagrilintide 2.4 mg) in combination with semaglutide 2.4 mg, compared with -9.8 percent on semaglutide alone

AstraZeneca Pharmaceuticals

Metformin Use with GLP-1 RA: Synergy Towards Better Outcomes Metformin with GLP-RA Effect on Weight-Lowering Response: A 52-week prospective study including 194 obese T2D patients showed concomitant initiation of metformin alongside GLP-1 receptor agonist therapy is associated with enhanced weight loss efficacy, suggesting a potential synergistic metabolic interaction that improves the likelihood of achieving clinically meaningful weight reduction

2021;33(4):833-844.e5