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starting on Day 17 with 2 /kg (panel A) of EC1456 ( ), three times per week (MAV/F) for a 2 week period, and compared to untreated animals ( ), as shown in FIG

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Additionally, a separate study of lobular distribution of hepatic P450 in SpragueDawley rats concluded that there were pronounced changes in hepatic lobular distribution of P450 enzymes from day 19 of gestation to forty-five days of age (Watanabe et al