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In particular, psilocybin (in a systemic LPS-induced inflammation model) has demonstrated potent effects in downregulating LPS-induced IL-1, IL-6, and Cyclooxygenase-2 (COX-2) mRNA levels in mouse liver [50], and other PSYs like MDMA have similarly been shown to attenuate stress-induced IL-1 in the hippocampus of rats [59]

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