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Hypoglycaemia risk is low when GLP-1 agonists are used alone but increases when combined with insulin or sulphonylureas

Ujiie H, Muramatsu K, Mushiroda T, Ozeki T, Miyoshi H, Iwata H, Nakamura A, Nomoto H, Cho KY, Sato N, Nishimura M, Ito T, Izumi K, Nishie W, Shimizu H

Without continuation, most patients regain this weight within weeks as hunger hormones return to baseline

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In this study, we utilized the ROR to identify NAE signals significantly associated with GLP-1 RAs, using contemporaneous FAERS reports of other medications as the reference cohort 26,27