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Smoking acutely activates the HPA axis resulting in increased cortisol levels [6,18], and nicotine is the principal component of tobacco responsible for the stimulation of the HPA axis [19]
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It has been demonstrated that (S)-NNN is preferentially metabolized by 2 hydroxylation whereas there is no preference for 2 hydroxylation versus 5 hydroxylation in the metabolism of (R)-NNN
1 2 3 4 5 ""Michael & McCartney": 1980s2009"
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