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Nicotine is the addictive substance present in tobacco products, including cigarettes and cigars

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It can help support bone density, cardiovascular health, skin elasticity, cognitive function, and metabolic balance

Meta-analyses and large cohort studies consistently report that smoking is associated with worse clinical outcomes among infected individuals, although interpretation is limited by residual confounding, smoking misclassification, and selection bias ( Evidence regarding infection risk is more heterogeneous, and the so-called smoking paradox remains controversial

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