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Adults were randomly assigned, 1:1:1:2, to once-daily 6 mg orforglipron, 12 mg orforglipron, 36 mg orforglipron or placebo for 72 weeks

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The mean age of participants was 58 years, and the mean duration of diabetes was 9 years

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Investigators studying combined-compound protocols often cite this non-overlap as the rationale for blend formats each compound contributes activity at a distinct molecular target without competing for the same receptor or downstream effector