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(NIH) In adults over 55 with type-2 diabetes, GSH supplementation improved glutathione stores and reduced DNA oxidative damage (8-OHdG) while lowering HbA1c.(NIH) However, short-term trials (4 weeks) in healthy adults showed no measurable change in blood GSH, highlighting absorption variability

These dynamics are top of mind and will be closely studied as better data become available

Trulicity (Dulaglutide) Injection, Prescribing Information

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This further supports the theory that the central and peripheral GLP-1 systems are not only anatomically but also functionally distinct