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The insulin-like growth factor 1 receptor (IGF1R) is a ubiquitously expressed membrane-bound tyrosine kinase receptor that recognizes its two major ligands IGF1 and IGF2, and controls multiple essential cellular functions [9]

To knockdown GCL by small hairpin RNA (shRNA), a vector-based shRNA approach using the targeting sequence 5-GAAGGAGGCTACTTCTATA-3, as we described 5 , was used

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