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In incretin-based trials, early weeks are often dominated by titration and tolerability: nausea, diarrhea, constipation, vomiting, appetite changes, and satiety shifts

Reconstituted solutions: Aqueous peptide solutions are susceptible to proteolytic degradation and microbial contamination

Bellanti et al., 2022

Recent studies also identified Yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) as key mechanoresponsive factors in the Hippo pathway to transmit blood flow-induced mechanical forces into intracellular signaling to affect EC phenotypes [223]

Biomolecules, 5(2), 545-589