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Any steroid taper must be done gradually under rheumatological supervision

Most participants were female (236 (77.6%)) and white (283 (93.1%)), with a mean (s.d.) age of 47.3 (11.0) years, body mass index of 38.5 (6.9) kg m 2 and weight of 106.0 (22.0) kg

In the SURMOUNT-1 clinical trial, participants on the maximum dose achieved an average of 22.5% body weight loss over 72 weeksthe highest weight reduction ever observed in a phase 3 obesity trial

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