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The pathogenesis of APE in this context is likely multifactorialranging from sympathetic hyperactivation and inflammatory responses to volume overload or pre-existing cardiopulmonary comorbidities [1, 5]

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associated current smoking status with higher risk of advanced disease status and lymph node metastases [47]

PETAs not aware of any recent studies using dogs in cigarette inhalation experiments, especially not for the development of tobacco products, which is banned in some countries

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