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"My gut reaction is that it will be a mixed bag," said Katharine Wibberly, director of the Mid-Atlantic Telehealth Resource Center, in an email to Fierce Healthcare

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Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

Finally, selective regulation within the sirtuin family is essential, as overactivation of SIRT1 could disrupt the functional balance of related sirtuins, necessitating careful control of activation intensity and tissue- or subcellular-specific delivery