Malate is the perfect complement to citrulline as Prez-Guisado et al points out Malateis capable of behaving as a metabolic shuttle between cytoplasm and mitochondria, enables bypassing of blockade of the oxidative pathway induced by ammonia, and hence limits accumulation of lactic acid by reorienting it toward pyruvate genesis and its aerobic utilization or neoglucogenesis
Crovesy, L., Ostrowski, M., Ferreira, D
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Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders
These were assessed with an HRP-conjugated polymer system (K5007, Dako, Germany) and a Leica DM2000 scanner (Leica Biosystems, Wetzlar, Germany)