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Thrombocytopenia and leukopenia also have been reported

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Treatment is often initiated at a high dose, followed by a maintenance dose given less frequently, as determined by the patient's B12 levels and clinical response

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To establish connection with the NO-system, L-NAME (5.0 mg/kg) (worsening) and L-arginine (200.0 mg/kg) (effective only with blunted NO-synthesis, but not alone) were given intraperitoneally alone or in combination (d-arginine 200.0 mg/kg was not effective, data not shown)

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