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You should speak to your GP or seek medical advice if: You are considering purchasing weight-loss injections from unregulated online sources You have a BMI of 30 kg/m or above and are struggling to manage your weight through lifestyle measures alone You have type 2 diabetes and your current treatment is not achieving adequate blood glucose control You are interested in finding out whether any clinical trials involving retatrutide or similar agents are recruiting near you Your clinician can also help you access structured weight management programmes through the NHS, which remain a cornerstone of evidence-based obesity care

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The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or Arrestin3 effectively

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