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Liver (hepatic) and kidney safety considerations are equally important, since some supplements that undergo hepatic metabolism or renal excretion can accumulate or interact with chemotherapeutic drugs leading to hepatotoxicity (e.g., kava, high-dose green tea extract) or nephrotoxicity in patients who already suffer from impaired organ function or taking chemotherapy agents known to be nephrotoxic such as cisplatin (208, 209)

For example, NAC consumption at a dose of 18 g/d for 12 weeks showed improvement in ovulation and pregnancy rates among patients with PCOS compared with 12 g daily after 12 weeks (Reference Nemati, Nemati and Taheri12,Reference Nasr9)

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The reduction in LDL-C and CRP levels in the GLP-1RA group suggests that these agents may also have anti-inflammatory and lipid-lowering effects