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Updated review of mechanisms
A recent meta-analysis of 11 cardiovascular outcome trials involving 55,921 patients treated with GLP-1 RAs and 43,306 patients treated with DPP-4 inhibitors also revealed no significant association between either drug class and pancreatic cancer risk
So, its something that you need to stay on it in order to continue with the benefits. Its a long-term commitment.
Discontinuation rates due to AEs: - Placebo: 4.9% - 4 mg: 4.1% - 9 mg: 6.9% - 12 mg: 11.3% The 11.3% discontinuation rate at the highest dose is a number worth watching