It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC
Extraocular muscle satellite cells are high performance myo-engines retaining efficient regenerative capacity in dystrophin deficiency
This will look different for different individuals, so it can be helpful to consider the extremes
60 mg/day for infants 7-11 months
The pharmacogenomic implication of polymorphic UGTs is presented, more specifically the role of UGT polymorphisms in modifying cancer risk and their impact on individual risk to drug-induced toxicities