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Norimoto et al., 2018), firing rates tend to decrease across individual REM sleep episodes (Grosmark et al., 2012

Restores NAD+ pools while activating AMPK

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SAM is additionally required for phosphatidylcholine synthesis, which is abundant in neuronal membranes and is crucial for synaptogenesis and neurite outgrowth ( Vitamin B12 is a cofactor for the enzyme methylmalonyl-CoA mutase, which converts methylmalonyl-CoA to succinyl-CoA, a crucial step in fatty acid metabolism (73)