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Pregnancy Category C

The costbenefit considerations must be carefully evaluated when expanding access to tirzepatide, particularly in resource-constrained health systems

Patients who have early Leber's disease (hereditary optic nerve atrophy) have been found to suffer severe and swift optic atrophy when treated with vitamin B12

Most important of these was Novo Nordisk demonstrating in a 17,000 patient five year clinical trial that Wegovy reduced the risk of major cardiovascular events (MACE) by 20%

This modification protects the peptide from rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-IV), extending its preclinical half-life relative to native GHRH