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On the other hand, the combination of immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 inhibitors, with ferroptosis inducers has been shown to significantly enhance therapeutic efficacy, particularly in ferroptosis-sensitive tumor cells (46)

[DOI] [PMC free article] [PubMed] [Google Scholar] 118.Doma-Magrowska D., Kowalski M.K., Maecka-Wojciesko E

Furin-mediated priming of viral S protein at S1/S2 (P R RA R 685 ) [the underlined AAs refer to critical residues needed for the furin recognition] is a key determinant in the pathogenesis of COVID-19 55,73,329

Outcomes vary and depend on individual factors

In the NMDA-induced olfactory bulbs (OB) excitotoxicity model, the expression of SIRT1 and SIRT4 in OB increased, while the expression of SIRT2 did not increase, which may be related to the recovery of olfactory function [123]