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Regarding intracellular roGFP2-based structure-function analysis of glutaredoxins, we now showed that the GSSG-dependent oxidation of the fused glutaredoxin moiety (and not the glutathionylation of the roGFP2 moiety) is rate-limiting unless saturating GSSG concentrations are present
doi: 10.1172/JCI25790
PloS One (2012) 7:e47045
The dynamic regulation of MORs at the plasma membrane following acute and chronic administration of opioids may therefore direct downstream signaling
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