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Despite these advances, several clinical challenges remain to be overcome

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Faster development and commercialization are also being facilitated by regulatory support for innovative treatments and accelerated approval processes for ground-breaking medications

In addition, transforming growth factor-1 (TGF-1), a potent fibrogenic protein, is known to upregulate astrocyte synthesis of proteoglycans causing severe gliosis (Yin et al., 2009

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