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doi: 10.3389/fbioe.2026.1814492 Received 20 February 2026 Revised 28 March 2026 Accepted 03 April 2026 Published 04 May 2026 Corrected 12 May 2026 Volume 14 - 2026 Edited by Chuan Li, National Yang Ming Chiao Tung University, Taiwan Reviewed by Md

So CagriSema applies two independent signals that both converge on decelerating the stomach: cagrilintide via amylin/AMY receptors in the area postrema and its vagal output, and semaglutide via GLP-1 receptors on vagal afferents and in the brainstem

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