Mechanistically, GLP1R is expressed at low levels in the heart and vasculature, raising the possibility that GLP1 might have both direct and indirect actions on the cardiovascular system
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IGF-1 and PDGF-bb suppress IL-1-induced cartilage degradation through down-regulation of NF-B signaling: involvement of Src/PI-3K/AKT pathway
A pre-specified meta-analysis of seven SURPASS trials demonstrated that tirzepatide was not inferior to placebo or active comparators, including insulin glargine, insulin degludec, semaglutide, and dulaglutide, in major adverse cardiovascular event (MACE) reduction [7]
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