Targeting the Nrf2/Heme oxygenase-1 pathway can significantly increase oxidative stress in RCC and promote apoptosis and death of cancer cells (104), while Heme oxygenase-1 has a dual role in ferroptosis induction (105)
doi:10.3390/molecules191119066 Vasireddi N, et al
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Categories of CAPS include three clinical subtypes: familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and chronic infantile neurologic cutaneous articular (CINCA) syndrome, also known as neonatal-onset multisystem inflammatory disease (NOMID)
During development and progression of atherosclerosis, Nrf2 signaling modulates many physiological and pathophysiological processes, like regulation of lipid homeostasis, CD36 gene expression regulation, foam cell formation, macrophage polarization, immunity regulation (Th2 differentiation and inhibition of pro-inflammatory gene expression through NFB down-regulation), redox regulation and inflammation, improvement of endothelial dysfunction, as well as GSH synthesis and utilization (234245)
