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41 Glucagon-like Peptide-1 (GLP-1) Agonists: Exenatide and liraglutide are GLP-1 receptor agonists that mimic the actions of GLP-1 and are resistant to dipeptidyl peptidase-IV degradation

The landmark STEP 1 trial demonstrated mean reductions of 14.9% over 68 weeks, making it one of today's most effective pharmaceutical interventions

Therefore, hormonal influence on taste cells may regulate taste signaling, but taste receptors seem to regulate local hormone release which indicates a fine-tuning mechanism for dietary feedback

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Because natural GLP-1 is rapidly broken down by DPP-4 in one to two minutes, it would need to be either administered continuously, or researchers would need to produce a mimic with improved stability that would last longer in the bloodstream