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Second, OS activates the polyol pathway, depleting NADPH reserves and reducing glutathione levels, leaving nerves vulnerable to lipid peroxidationa process evidenced by 3-fold higher levels of 4-HNE in sural nerve biopsies from diabetic patients with neuropathy compared to controls (Pop-Busui et al., 2016)

While clinical studies have established that 2-DG can be safely administered to humans [89], its potential application in TB treatment is limited, particularly due to its effectiveness only when administered before infection

In phase 3 studies, any site reaction was present in 0.6% of patients on the 0.5 mg dose, 0.3% on the 1 mg dose, and 0.8% in the comparator groups

But they are chemically different things that do different jobs